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Correcting Dermal Filler Complications
Published 3rd June 2024
min read
Expert Reviewed By
Dr Anna Hemming recounts how she handled a rare & particularly challenging complication
At 1.42 pm, on a lunchtime, the notification of an email innocently arrived on my screen. As I was between I saw the first few words:
I didn’t want to bother you, but I thought I would check, is this normal?
Normally, I would leave my experienced team to deal with all patient emails, however, this was a I had treated with the previous day and, knowing the patient, something within the email didn’t seem right. Moments later, I was on the phone with her, asking if she was in pain (no), there was any blanching (yes), and other . A photo immediately arrived of the kind we have all seen at . This was not normal, and we needed to bring her in. Being 90 away from the clinic, she arrived as soon as she could.
In the meantime, the clinic ran as normal, patients were seen, and, in the back of my mind, my file was being pulled out and the algorithm for vascular occlusion (VO) ran . By the time the arrived at the clinic, I had reviewed her notes (after images were normal, no mottling and no refill time (CRT), reviewed the ACE guidelines for VO, and had all the emergency drugs at hand, just in case.
My is a 42 with asymmetry. I had treated her 12 months previously with dermal filler with great success. Her 12-month review had recently passed and there was volume loss to the temple, medial and lateral suborbicularis oculi fat (SOOF), as well as the tear trough. Her left side was always more than the right and we had a plan to stabilise the deep fat pads, deep and then review, to address the tear trough depressions.
At the review, the tear trough filler was used to lift the under-eye, especially on the left. The immediate results were lovely, there was no pain or unusual after-effects, until seven hours after the filler, when the patient noticed some (she thought initially it was the local from the treatment).
In the evening, the area was slightly pinker, but it wasn’t until the next day and 24 hours after treatment that she emailed, as the area was still a bit pink.
HOW TO ASSESS POTENTIAL VO
Patients are often in pain, have CRT in the area and surrounding skin, and display pallor and then .
Immediate action is required if there is any suspicion of VO or spasm of the nerves causing hypoxia to the skin.
Rapid action is necessary to reverse the before necrosis establishes, leading to tissue breakdown and wounds.
In this patient, the pallor stage was not in clinic, at 24 hours in the livedo reticularis phase.
Phases of a VO
1. Pallor – Occurs with immediate blockage of an arteriole as the blood flow is and blocks tissue perfusion. Lasts seconds – or persists longer.
2. Livedo reticularis – A mottled pattern appears on the skin from the of blood from the venous network. Can occur rapidly, lasting hours.
3. Pustules – Typically at 72 hours due to the in pH and sweat, along with changes due to hypoxia allowing staph. aureus bacterial overproduction.
4. Coagulation – change and can occur before pustule . Caused by worsening hypoxia, the skin as cell lysis occurs and there is a of blood into the . Skin tissue remains firm due to the coagulative necrotic process.
5. Tissue destruction – Skin breaks down due to a build-up of structural proteins (collagen, fibrin, elastin) neutrophils, bacteria, and haemoglobin. tissue is initially moist creamy/yellow or green (slough) and then becomes black (dark) and dry. This occurs days after the occlusion.
HOW TO TREAT A VO?
• Stop (if they are with you) and inform them about what is happening
• Check and video CRT on both affected and unaffected skin for comparison
• If CRT is delayed, it indicates compromise
• Massage the area firmly, applying heat to encourage vasodilation
• Assess
• Get help
• Hyaluronidase (do not skin test, ensure medications are at hand just in case)
• Disinfect the skin
• Reconstitute 1500 hyaluronidase in 1ml NaCl 0.9% or 1-2% lidocaine
• Infiltrate 1500IU by needle or cannula throughout the affected artery and wider area of . More than one vial may be needed
• Apply heat and massage area vigorously (helps mechanical breakdown of HA)
• Assess CRT and if >3 seconds repeat hyaluronidase hourly
• Review patient daily
• Clinical may be required over the following days to avoid deterioration
• Make notes and take images and videos
• Advise insurers so they are aware of the situation.
that may help Aspirin or 300mg stat and 75mg per day.
The following may also help reverse compromise:
• Nitroglycerin paste
• oxygen
• Steroids only if clinical indication
• Wound management
• if tissue has started to break down
• Antibiotics.
PROGRESS OF THIS PATIENT’S VASCULAR EVENT
On arrival in clinic the day after dermal filler treatment, we talked through the openly. She was not in pain; her CRT was sluggish in the area and the vascular . Livedo reticularis was present with erythema and even of the tissue in the distal vascular pathway.
My gut was the vessel had experienced a spasm, affecting the distal branches to the skin.
With open we her . Immediate aspirin, hyaluronidase and were started due to the presentation, to try to decrease and .
Day two
As I was attending a conference 10 minutes away from her the following day, we planned to review at the conference, where I a private room and place where we could treat her again. 1500IU of was administered, exosomes were started topically and after consulting with colleagues a short course of prednisolone commenced.
Day three
We arranged starting the following day along with review and a further 1500IU as the area was still firm. Tiny white started to appear in the apical to the side of the nose. The was shrinking and the numbness was improving.
Day four
The area was one last time with 1500IU hyaluronidase and a further chamber attended. from hyaluronidase flooding can be seen in the filler area.
Day five
A small area in the apical triangle has for breakdown.
Day seven
The has a further hyperbaric session. The bruising, and vascular settled and the apical crusting was mildly better.
Day 10
Further session
Day 12
Day 16
Day 45
Day 12, 16 and 45 saw huge improvements in the look and feel of skin, with numbness. The patient was left with a small amount of erythema. The apical triangle intact and didn’t .
IN TOTAL
• 9 appointments
• 4 x 1500 IU hyaluronidase
• Aspirin 300mg stat, 75mg OD
• Flucloxacillin 500mg QDS 7/7
• Prednisolone 40mg OD 5D
• 5 sessions
We have our next review and aim to help resolve the erythema in completion with laser genesis or excel V+ .
The patient is hugely that we were able to get on top of the vascular event as soon as we were aware of it. She is happy with our treatment.
This article was originally in . June 2024.
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